Visionary scientist Janos Rukh convinces a group of scientists and supporters to mount an expedition to the African continent to locate and study an ancient meteorite of great significance. He exposes himself to the highly toxic radiation of the meteorite, and while an antidote devised by Dr. Benet saves him from death by radiation poisoning, his naked touch causes instant death to others.

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A mysterious plague, the Purple Death, ravages the earth. Dr. Zarkov, investigating in his spaceship, finds a ship from planet Mongo seeding the atmosphere with dust. Sure enough, Ming the Merciless is up to his old tricks.

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